71st SIF National Congress

71st SIF National Congress

The Italian Society of Physiology

The Italian Society of Physiology

Milan (Online) • 7-9 September 2021

Milan (Online)
7-9 September 2021

Programme

Programme overview

  • Tuesday, 7 September

    13:30-14:00

    Welcome messages [Hall A]

    14:00-15:00

    Opening Lecture [Hall A]

    José López Barneo (University of Seville, Spain)
    Acute oxygen sensing and regulation of breathing

    Symposium 1: Cognitive and visuomotor functions in human and non-human primates [Hall A]
    Chair: Rossella Breveglieri (Bologna)

    15:00-15:20

    Rossella Breveglieri (University of Bologna, Italy)
    Visuomotor functions of the medial posterior parietal cortex of monkeys and humans

    15:20-15:40

    Simona Monaco (University of Trento, Italy)
    Decoding action intention with and without visual information from the activity pattern in the human early visual cortex

    15:40-16:00

    Celia Foster (Bielefeld University, Germany)
    An expansion of the macaque ventral intraparietal area in the human brain

    15:00-16:20

    David Pascucci (École Polytechnique Fédérale de Lausanne, Switzerland)
    Modeling large-scale dynamic brain networks during perception and cognition

    Symposium 2: Astrocytes-mediated brain handling of neurotoxic molecules [Hall B]
    Chair: Roberto Piacentini (Rome) and Alexej Verkhratsky (Manchester, UK)

    15:00-15:20

    Myriam Catalano (Sapienza University of Rome, Italy)
    Kv1.3 activity modulates astrocyte glutamate buffering

    15:20-15:40

    Laura Civiero (University of Padua, Italy)
    Astrocyte phagocytic activity: mechanisms in health and disease

    15:40-16:00

    Roberto Piacentini (Università Cattolica del Sacro Cuore, Rome, Italy)
    Glypican 4 is involved in extracellular tau oligomers internalization in astrocytes

    16:00-16:20

    Alexej Verkhratsky (University of Manchester, UK)
    Astrocyte iron homeostasis: links to astrogliosis and neurodegeneration

    Oral Communications: Cell Physiology 1 [Hall C]
    Chair: Annarita Di Mise (Bari)

    15:00-15:15

    Rosario Amato (Pisa)
    Novel insights into beta 3 adrenergic receptor regulation by oxygen levels in the retina: evidence from the model of oxygen-induced retinopathy

    15:15-15:30

    Giorgia Bertoli (Milan)
    Electrophysiological characterization of the compound heterozygosity (K1578N-G1866fs) of the cardiac sodium channel (Nav1.5) identified in a young patient affected by sinus node dysfunction

    15:30-15:45

    Giorgia Chinigò (Turin)
    TRPM8-Rap1A interaction inhibits prostate cancer cell adhesion and migration

    15:45-16:00

    Annarita Di Mise (Bari)
    Pre-clinical evaluation of dual targeting of the G protein-coupled receptors, CaSR and V2R, for treating Autosomal Dominant Polycystic Kidney Disease (ADPKD)

    16:00-16:15

    Marco Fiocchetti (Rome)
    Physiological outcomes of a novel estrogen-induced cell signaling pathway

    Oral Communications: Neurobiology and Neurophysiology 1 [Hall D]
    Chair: Giovanni Mirabella (Brescia)

    15:00-15:15

    Francesca Ginatempo (Sassari)
    Cerebellar learning is modulated by the view of faces expressing sadness

    15:15-15:30

    Anita Monteverdi (Pavia)
    Integration of cerebro-cerebellar loops improves virtual brain models of neurodegenerative diseases

    15:30-15:45

    Ileana Montagna (Pavia)
    Microendoscopic calcium imaging in the cerebellum of freely-moving mice

    15:45-16:00

    Giovanni Mirabella (Brescia)
    Facial emotional stimuli affect movement preparation, execution and inhibition only when they are task-relevant

    16:00-16:15

    Walter Gulisano (Catania)
    The Lightmouse project: a complete open-source behavioral system from hardware to AI-based analysis software to study cognition in rodents

    16:20-16:30

    Break

    Symposium 3: Sleep as a phenomenon of the integral organism: recent advances on an old theme [Hall A]
    Chair: Alessandro Silvani (Bologna)

    16:30-16:50

    Simone Sarasso (University of Milan, Italy)
    Sleep-like cortical reactivity during wakefulness following brain injury

    16:50-17:10

    Ugo Faraguna (University of Pisa, Italy)
    Tracking sleep physiology in the age of wearable technologies

    17:10-17:30

    Alessandro Silvani (University of Bologna, Italy)
    Recent advances in cardiovascular and motor control during sleep: a translational perspective

    17:30-17:50

    Dragana Rogulja (Harvard Medical School, USA)
    Sleep and the gut

    Symposium 4: What’s new on V̇O2 kinetics? Mechanistic insight and practical implications for exercise testing and prescription [Hall B]
    Chair: Silvia Pogliaghi (Verona)

    16:30-16:50

    Silvia Pogliaghi (University of Verona, Italy)
    V̇O2 slow component: what’s new?

    16:50-17:10

    Alessandro L. Colosio (Ghent University, Belgium)
    Bioenergetics of the V̇O2 slow component between exercise intensity domains

    17:10-17:30

    Øyvind Nøstdahl Gløersen (Norvegian School of Sport Science, Oslo, Norway)
    Modelling V̇O2 on-kinetics: is it time for a critical revisitation of the traditional 3-phase model?

    17:30-17:50

    Lucrezia Zuccarelli (University of Udine, Italy)
    Comparison between slow components of heart rate and V̇O2 kinetics: functional significance and practical implications for exercise administration

    Oral Communications: Cell Physiology 2 [Hall C]
    Chair: Michele Maffia (Lecce)

    16:30-16:45

    Marilina Florio (Bari)
    Heterologous production and functional reconstitution of a human aquaglyceroporin of broad selectivity (AQP9)

    16:45-17:00

    Federica Giannetti (Milan)
    hiPS-cardiomyocytes for studying a specific mutation in PITX2 gene and its role atrial fibrillation insurgence

    17:00-17:15

    Michele Maffia (Lecce)
    Copper dyshomeostasis in synucleinopathies: a potential role for PLK2 kinase as a counter for a-synuclein aggregation and oxidative stress

    17:15-17:30

    Simona Martinotti (Alessandria)
    Endothelial integrity recovery: a honey, H2O2 and calcium story

    17:30-17:45

    Valentina Melfi (Milan)
    The neuroactive steroid ALLO mediates the dualistic role of PKCε in Schwann cell and peripheral sensory neurons

    17:45-18:00

    Vincenzo Migliaccio (Salerno)
    Beneficial effect of hydroxytyrosol against palmitate-induced lipotoxicity in HepG2 cells: a possible role for mitochondrial fusion and fission balance

    Oral Communications: Neurobiology and Neurophysiology 2 [Hall D]
    Chair: Fabrizia Cesca (Trieste)

    16:30-16:45

    Beatrice Badone (Ballerup, Denmark)
    High throughput screening using QPatch II and Qube 384 systems: electrophysiological evaluation of primary neurons, glial cells and hiPSC-derived motor neurons

    16:45-17:00

    Veronica Bonalume (Milan)
    Axonal GABAA receptor stabilises excitability in unmyelinated nociceptor axons secondary to NKCC1 shift in ECl-

    17:00-17:15

    Barbara Barile (Bari)
    Impact of AQP4 supramolecular organization in migrating reactive astrocytes

    17:15-17:30

    Fabrizia Cesca (Trieste)
    Kidins220/ARMS mediates astrocyte developmental switch in BDNF sensitivity, calcium signaling and neuron-astrocyte communication

    17:30-17:45

    Elisabetta Catalani (Viterbo)
    The pathophysiology of retina neurons through the eye of the fruit fly Drosophila melanogaster

    17:45-18:00

    Ilaria Piano (Pisa)
    MicroRNA-155 is a target to slowing down retinal neuron degeneration in a Retinitis Pigmentosa mice model

    17:50-18:15

    Break

    18:20

    pH Lecture [Hall A]

    Lamberto Maffei (Pisa)
    Matrimonio tra arte e cervello; officiante il cervello

  • Wednesday, 8 September

    9:00-10:30

    Poster Session 1: Cell Physiology

    10:30-11:00

    Break

    11:00-12:30

    Poster Session 2: Cell Physiology & Metabolism, Nutrition and System Physiology

    14:00-15:00

    Herlitzka Lecture [Hall A]

    Matteo Carandini (UCL, London, UK)
    Recording from a myriad neurons

    Symposium 5: An intracranial insight on sensori-motor awareness [Hall A]
    Andrea Pigorini and Luca Fornia (Milan)

    15:00-15:20

    Gabriele Arnulfo (University of Genoa, Italy)
    Mapping human brain network(s) using sEEG: challenges and breakthroughs

    15:20-15:40

    Maria Del Vecchio (Consiglio Nazionale delle Ricerche, Parma, Italy)
    Tonic somatosensory responses as the neural fingerprint of tactile awareness

    15:40-16:00

    Andrea Pigorini (University of Milan, Italy)
    Loss of differentiation and complexity in the sleeping human brain: a multi-scale analysis

    16:00-16:20

    Luca Fornia (University of Milan, Italy)
    Direct electrical stimulation of the premotor cortex shuts down awareness of voluntary actions

    Symposium 6: Nutrition in pregnancy: effects on the physiology of maternal uterine circulation and feto-placental unit development [Hall B]
    Maurizio Mandalà (Cosenza)

    15:00-15:20

    Elizabeth Cottrell (Univeristy of Manchester, UK)
    Therapeutic potential of beetroot juice in pregnancy

    15:20-15:40

    Teresa Tropea (Univeristy of Manchester, UK)
    Beneficial effects of grape seed extract polyphenols in pregnancy

    15:40-16:00

    Maurizio Mandalà (Calabria University, Italy)
    Effects of Bisphenol A on maternal uterine vasculature and on feto-placental development

    16:00-16:20

    Francesca Ietta (University of Siena, Italy)
    Metabolic heart adaptation in fetal rats exposed to Bisphenol A

    Oral Communications: Cell Physiology 3[Hall C]
    Giulio A Sancini (Milan)

    15:00-15:15

    Serena Milano (Bari)
    β3-adrenoreceptor participates in the sympathetic regulation of the renal acid-base homeostasis

    15:15-15:30

    Sharon Negri (Pavia)
    Optical stimulation of endothelial colony forming cells plated on light-sensitive conjugated polymers induces a TRPV1-mediated increase in intracellular Ca2+ concentration

    15:30-15:45

    Sofia Passaponti (Siena)
    Placenta-brain axis: focus on astrocytes

    15:45-16:00

    Giulio A Sancini (Milan)
    Considerations around the SARS-CoV-2 spike protein, airborne particulate matter and SARS-CoV-2 brain infection

    16:00-16:15

    Rocco Zerlotti (Munich, Germany)
    Solid supported membrane-based electrophysiology (SSME) meets SGLT1 and GAT1

    Oral Communications: Metabolism, Nutrition and System Physiology [Hall D]
    Assunta Lombardi (Naples)

    15:00-15:15

    Alex Buoite Stella (Trieste)
    Climate change and heat illness risk: a matter for physiologists

    15:15-15:30

    Luisa Cigliano (Naples)
    Effect of short-term fructose-rich diet on brain: what is reversible and what persists after sugar removal from the diet?

    15:30-15:45

    Daniele La Russa (Arcavacata di Rende, CS)
    Caloric restriction mitigates kidney fibrosis and apoptosis in an aged and obese rat model

    15:45-16:00

    Rita Polito (Foggia)
    Effects of very low calorie ketogenic diet on autonomic nervous system activity

    16:00-16:15

    Assunta Lombardi (Naples)
    Ablation of UCP3 affects visceral white adipose tissue functionality

    16:20-16:30

    Break

    Symposium 7: Passive exercise and vascular function: physiological mechanisms and translational insight [Hall A]
    Fabio Esposito (Milan) and Richardson Russel (Salt Lake City, UT, USA)

    16:30-16:50

    Emiliano Cè (University of Milan, Italy)
    Long-term passive static stretching and vascular function

    16:50-17:10

    Joel Trinity (University of Utah, USA)
    Passive leg movement and the endothelium: looking beyond NO

    17:10-17:30

    Massimo Venturelli (University of Verona, Italy)
    Passive leg movement-based training: the vascular impact

    17:30-17:50

    Walter Wray (University of Utah, USA)
    Vascular function and blood flow regulation in patients with heart failure

    Symposium 8: New vistas on cerebellar circuit dynamics [Hall B]
    Egidio D’Angelo (Pavia)

    16:30-16:50

    Lisa Mapelli & Claudia Casellato (University of Pavia, Italy)
    Single neurons and circuits of the cerebellum

    16:50-17:10

    Jil Mona Meier (Charité Universitätsmedizin Berlin, Germany)
    Cerebellar dynamics in virtual brain simulators

    17:10-17:30

    Fulvia Palesi (University of Pavia, Italy)
    Exploring the cerebellum in humans through MRI recordings and virtual brain modelling

    17:30-17:50

    Silvia Marchese (University of Milan, Italy)
    Virtual brain modelling in cerebellar ataxic patients

    Oral Communications: Neurobiology and Neurophysiology 3 [Hall C]
    Marco Luppi (Bologna)

    16:30-16:45

    Carmen Murano (Milan)
    Functional characterization of a novel HCN2 variant associated with progressive epileptic encephalopathy in neonatal rat neurons

    16:45-17:00

    Marlene E Pfeffer (Genoa)
    Engineering of azobenzene-derived membrane-targeted photoswitches for light-driven modulation of neuronal activity

    17:00-17:15

    Ingrid Reverte (Rome)
    Effect of social choice-induced voluntary abstinence on incubation of methamphetamine craving and AMPA receptor expression in nucleus accumbens core

    17:15-17:30

    Marco Luppi (Bologna)
    Synthetic torpor stimulates a latent physiological neuroprotective process able to cope with the brain accumulation of hyperphosphorylated tau protein

    17:30-17:45

    Maria Rosaria Tropea (Catania)
    A failure of Amyloid-β physiological function due to deletions of α7 nicotinic acetylcholine receptors triggers an Alzheimer’s disease-like pathology

    17:45-18:00

    Chiara Piantoni (Hannover, Germany)
    Age-related changes in cardiac autonomic modulation and heart rate variability in mice

    Oral Communications: Metabolism and Neurobiology [Hall D]
    Valentina Pallottini (Rome)

    16:30-16:45

    Valentina Pallottini (Rome)
    Maternal exposure to very low dose of BPA induces alteration of mevalonate pathway in the liver and brain of rat fetuses

    16:45-17:00

    Eleonora Solari (Varese)
    Involvement of TRPVs channels in the response to fluid osmolarity by rat diaphragmatic lymphatic vessels

    17:00-17:15

    Maria Grazia Zizzo (Palermo)
    Does Angiotensin II contractile response undergo to age-related  changes in rat jejunum?

    17:15-17:30

    Mariangela Centrone (Bari)
    Vasopressin downregulates the AQP3 function via V1aR in human colon HCT8 cells

    17:30-17:45

    Giuseppina D'Alessandro (Rome)
    Environmental signals modify gut microbiome and metabolome enhancing neural plasticity through short-chain fatty acids

    17:45-18:00

    Tiziana Romanazzi (Varese)
    The interaction of bile acids with dopamine transporter heterologously expressed in Xenopus laevis oocytes

    17:50-18:15

    Break

    18:20

    Plenary Lecture [Hall A]

    2019 Nobel Laureate in Physiology or Medicine
    Gregg L. Semenza (Johns Hopkins University, Baltimore, MD, USA)
    Hypoxia-Inducible Factors in Physiology and Medicine
    Sponsored by Umana Medical a brand of GPI, Malta

  • Thursday, 9 September

    9:00-10:30

    Poster Session 3: Neurophysiology and Neurobiology

    10:30-11:00

    Break

    11:00-12:30

    Poster Session 4: Neurophysiology and Neurobiology & Physiology of Motor System and Exercise

    14:00-15:00

    Ruzzier Lecture [Hall A]

    Marco Linari (University of Florence, Italy)
    The role of thick filament mechanosensing in the Starling law of the heart

    Symposium 9: New insights on neuromuscular control through advanced High Density EMG analysis [Hall A]
    Daniele Borzelli (Messina)

    15:00-15:20

    Kohei Watanabe (Chukyo University, Toyota, Japan)
    Regional activation within human rectus femoris muscle; physiological/biomechanical background and methodological applications

    15:20-15:40

    Daniele Borzelli (University of Messina, Italy)
    CNS exploits separate interneuronal pathways to control force and cocontraction

    15:40-16:00

    Taian Martins Vieira (Politecnico di Torino, Italy)
    Physiological and technical insights gained into the assessment of muscle function from a combined approach: high-density surface EMG and electrical stimulation

    16:00-16:20

    Simone Tanzarella (IIT, Genoa, Italy)
    Motor neuron synergistic organization in complex hand gestures

    Symposium 10: Unconventional pathways and targets in the onset of cardiac arrhythmias [Hall B]
    Marcella Rocchetti and Annalisa Bucchi (Milan)

    15:00-15:20

    Ji-Dong Fu (The Ohio State University, USA)
    MicroRNA modulates cardiac electrophysiology via direct binding to ion channel

    15:20-15:40

    Pier Leopoldo Capecchi (University of Siena, Italy)
    Autoimmune channelopathies as a novel mechanism in cardiac arrhythmias

    15:40-16:00

    Maria Fernandez Velasco (Hospital Universitario La Paz, Madrid, Spain)
    Innate immune receptors, key actors in cardiovascular diseases

    16:00-16:20

    Ilaria Rivolta (University of Milan Bicocca, Italy)
    KNa1.1: a novel player in cardiac electrophysiology

    Oral Communications: Motor System and Exercise [Hall C]
    Feliciano Protasi (Chieti)

    15:00-15:15

    Riccardo Borzuola (Rome)
    Neuromuscular electrical stimulation affects spinal excitability but not cortical activity of the somatosensory cortex

    15:15-15:30

    Roberto Panichi (Perugia)
    Motor control of upper limb movement: functional significance of sensory overactivation and visual-proprioceptive interaction

    15:30-15:45

    Veronica Farinelli (Milan)
    A novel viewpoint on anticipatory postural adjustments during gait initiation

    15:45-16:00

    Feliciano Protasi (Chieti)
    Calcium Entry Units: focus on the alternative door for calcium ions in skeletal muscle

    16:00-16:15

    Anna Taboni (Geneva, Switzerland)
    Baroreflex and operating point dynamics at exercise onset in hypoxia

    16:20-16:25

    Concluding Remarks [Hall A]

    16:30-18:30

    SIF General Assembly [Hall A]

  • Posters

    Poster Session 1 • Wednesday, 8 September • 9:00-10:30

    Cell Physiology

    P1.1 Cristiana Alberghina (Catania)
    Radiotherapy-induced effects on microglia support glioblastoma growth and malignance by tumor microenvironment alteration

    P1.2 Claudia Altomare (Lugano, Switzerland)
    Atrial-like cardiomyocytes derived from human pluripotent stem cells: in vitro modeling of atrial cardiomyopathies

    P1.3 Martina Arici (Milan)
    The long-lasting istaroxime metabolite PST3093 stimulates SERCA2a and reverses disease-induced changes in cardiac function

    P1.4 Madelaine Audero (Turin)
    Acidic microenvironment promotes Pancreatic Ductal Adenocarcinoma (PDAC) cells selection inducing more aggressive cancer cells: role of Store-Operated Ca2+ signals

    P1.5 Francesca Baldini (Genoa)
    Characterization of chromatin architecture during malignant transformation of neuroblastoma cells by optical nanoscopy

    P1.6 Amilcare Barca (Lecce)
    Morpho-functional evidence of inflammatory sensitivity acquisition by Caco-2 cell monolayers after spontaneous differentiation towards the epithelial enterocyte-like cell phenotype

    P1.7 Patrizia Benzoni (Milan)
    iPSC-derived cardiomyocytes as a model to dissect electrical and mechanical dysfunctions of caveolinopathies

    P1.8 Giuseppe Calamita (Bari)
    Ablation of Aquaporin-9 improves the systemic inflammation of LPS-induced endotoxic shock in mouse

    P1.9 Maurizio Cammalleri (Pisa)
    Gabapentin as a novel treatment for ocular pain

    P1.10 Rosa Cardone (Bari)
    Development of 3D-organotypic cultures for the analysis of NHE1 in epithelial remodeling during pancreatic morphogenesis

    P1.11 Annunziata Gaetana Cicatiello (Naples)
    Type 2 deiodinase-mediated intracellular activation of Thyroid Hormone promotes myogenic differentiation by regulating mitochondrial reactive oxygen species generation

    P1.12 Marika Cordaro (Messina)
    Exposure to Atrazine worsens bleomycin-induced pulmonary fibrosis by Nrf-2 pathways and induces behavioral alterations

    P1.13 Alessandro Cospito (Milan)
    Knock out of the GNB5 gene associated with the IDDCA syndrome alters the intrinsic and extrinsic rate of sinoatrial-like cells

    P1.14 Simona D'Aprile (Catania)
    Sonoporation induces specific internalization in tumor cells leading to a temporary alteration of the vascularization

    P1.15 Ilaria Di Gregorio (Fisciano, SA)
    Omega 3 effect on cell viability and mitochondrial dynamics: a focus on fusion/fission balance into liver cancer cells treated with EPA, DHA and capecitabine

    P1.16 Pawan Faris (Pavia)
    Hydrogen peroxide induces extracellular Ca2+ entry and apoptosis via transient receptor potential ankyrin 1 (TRPA1) channel activation in primary culture of metastatic colorectal carcinoma

    P1.17 Mariacristina Filice (Arcavacata di Rende, CS)
    Mitochondrial changes in the cardiac response to hypoxia of the goldfish Carassius auratus

    P1.18 Alessandra Galli (Milan)
    Mechanotransduction boosts the pancreatic β-cell function by inducing a mitomorphosis program

    P1.19 Andrea Gerbino (Bari)
    Proinflammatory cytokines as emerging molecular determinants in cardiolaminopathies

    P1.20 Simona Lobasso (Bari)
    Effects of in vivo treatment with the novel mitochondria-targeted peptide elamipretide on lipid profile of cardiac mitochondria in a murine model of Barth Syndrome cardiomyopathy

    P1.21 Martina Lucchesi (Pisa)
    Oxygen-dependent expression of beta-adrenoceptors and members of the HIF-1/VEGF axis in human Müller and retinal endothelial cells

    P1.22 Rosa Mancinelli (Chieti)
    Training-dependent effect of exosomes on skeletal muscle regeneration

    P1.23 Alessandro Marrone (Arcavacata di Rende, CS)
    Effects on protein phosphorylation during postmortem: biomedical and forensic implications

    P1.24 Dario Melgari (San Donato Milanese (MI))
    Electrophysiological characterization of a NEU3 sialidase overexpressing system in H9c2 cell line

    P1.25 Donatella Mentino (Bari)
    Altered AQP3 expression and distribution in the epidermis Hidradenitis suppurativa patients

    P1.26 Tasnim Mohamed (Milan)
    Hearing-loss related genes are deregulated by electromagnetic field exposure in vestibular schwannoma cells

    P1.27 Caterina Morabito (Chieti)
    Simulated microgravity affects cellular physiology: a comparison between adherent and suspension cell lines

    P1.28 Rossana Morabito (Messina)
    Kir2.1 channel in an oxidative stress-related model of aging neuroglia

    P1.29 Annarita Nappi (Naples)
    Selective inhibition of genomic and non-genomic effects of thyroid hormone tegulates muscle cell differentiation and metabolic behavior

    P1.30 Maria Pagano (Messina)
    The response of digestive cells of Mytilus galloprovincialis after exposure to thiacloprid

    Poster Session 2 • Wednesday, 8 September • 11:00-12:30

    Cell Physiology

    P1.31 Teresa Pasqua (Germaneto (CZ))
    Another brick in the wall of cardioprotection: the role of Catestatin via macrophages immunosuppression

    P1.32 Serena Penna (Salerno)
    Protective effect of hydroxytyrosol on toxicity induced by the environmental pollutant dichlorodiphenyldichloroethylene (DDE) in liver cells in vitro (HepG2)

    P1.33 Francesca Piccapane (Bari)
    Functional characterization of transport across peritoneal mesothelium

    P1.34 Giusy Pietrafesa (Potenza)
    Rescue of the homeostasis in cells expressing the pathogenic LMNA variant R321X by nonsense mutation readthrough and the ER stress inhibition

    P1.35 Marianna Ranieri (Bari)
    In vivo treatment with calcilytic reverses the reduced expression of AQP2 and the higher AQP2-targeting miRNA-137 levels in Calcium-Sensing Receptor (CaSR) Knock-In mice mimicking Autosomal Dominant Hypocalcemia (ADH)

    P1.36 Alessia Remigante (Genoa)
    Specific activation of BK potassium channels has no effect on cell viability, proliferation and migration in melanoma and pancreatic adenocarcinoma cell lines

    P1.37 Carmine Rocca (Arcavacata di Rende, CS)
    Interaction of the novel endogenous peptide Cateslytin with Toll Like Receptor 4: mechanism of action and cardioprotection

    P1.38 Sara Sergio (Lecce)
    The β-catenin/c-Myc axis acts as a molecular switch in the regulation of the autophagy process during hyperammonemia in the Huh7 cell line

    P1.39 Sara Spinelli (Messina)
    Effect of Quercetin on d-Galactose aging model in human erythrocytes

    P1.40 Michela Terlizzi (Fisciano, SA)
    Sphingosine-1-phosphate is involved in lung cancer-related inflammation

    P1.41 Eleonora Torre (Montpellier, France)
    Genetic ablation of G protein-gated inwardly rectifying K+ channels improves heart rate in Angiotensin II-induced sinus bradycardia mice model

    P1.42 Paola Venditti (Naples)
    Oxidative damage and mitochondrial functionality in hearts from KO-UCP3 mice housed at thermoneutrality

    P1.43 Maria Venneri (Bari)
    Disruption of the ser-269 in the AQP2 abolishes the gain-of-function phenotype in renal cells expressing the V2R-R137L/C mutants causing Nephrogenic Syndrome of Inappropriate Antidiuresis (NSIAD): functional implication in AQP2 trafficking

    Metabolism, Nutrition and System Physiology

    P2.1 Antonella Amato (Palermo)
    Indicaxanthin from Opuntia Ficus Indica fruit prevents the glucose dismetabolism in obese mice

    P2.2 Patrizia Gena (Bari)
    Adipose and hepatic aquaglyceroporins in energy balance in health and disease

    P2.3 Alessandro Leone (Milan)
    Long-term effect of a daily consumption of Moringa oleifera leaf powder on blood pressure: a 3-months pilot study in Saharawi diabetic women

    P2.4 Andrea Manca (Sassari)
    Differences in fat oxidation rates during moderate aerobic exercise among healthy aged and younger women and mildly disabled women with multiple sclerosis: a pilot study

    P2.5 Arianna Mazzoli (Naples)
    Persistence of fructose-induced gut dysfunction after switching to a healthy diet

    P2.6 Melania Melis (Monserrato, CA)
    A machine learning approach to evaluate taste sensitivity

    P2.7 Marina Montagnani Marelli (Milan)
    The vitamin-E derived delta-tocotrienol overcomes drug-resistance by triggering necroptosis in prostate cancer cells

    P2.8 Gaetana Napolitano (Naples)
    Aluminum chronic exposure affects the redox state of zebrafish gills

    P2.9 Chiara Ottaviani (Varese)
    Lumbricus terrestris as a simplified animal model to approach the study of the intrinsic contractility of vertebrate lymphatic vessels: a pilot study

    P2.10 Matteo Pecchiari (Milan)
    Non-invasive assessment of intrinsic positive end-expiratory pressure

    P2.11 Sophia Schumann (Padua)
    Investigation on accumulated PFAS impact on the stress response in freshwater fish of the Veneto Region

    P2.12 Rosalba Senese (Caserta)
    3,5-diiodo-L-thyronine (T2) counteracts inflammatory state in rats receiving long-lasting high-fat diet through activation of Irisin-SIRT1 pathway

    P2.13 Giorgia Sollai (Monserrato, CA)
    Olfactory sensitivity is associated with body mass index and polymorphism in the voltage-gated potassium channels Kv1.3

    P2.14 Giovanna Trinchese (Naples)
    The impact of mitochondrial dysfunction on metabolic and inflammatory profile in an animal model of the autism spectrum disorders (ASD)

    P2.15 Giovanna Valenti (Bari)
    Renal physiology in simulated microgravity

    P2.16 Lucia Ventura (Sassari)
    Sex-based differences in substrate oxidation during moderate-intensity aerobic exercise

    P2.17 Laura Vergani (Genoa)
    Beneficial effects of carvacrol on in vitro models of metabolically-associated dysfunctions may be hindered by excess circulating  fatty acids interfering with the carvacrol binding to serum albumin

    P2.18 Tiziano Verri (Lecce)
    Structure-function relationships in three teleost fish PepT2-type transporters isolated from two teleost fish models, the zebrafish (Danio rerio) and the Atlantic salmon (Salmo salar)

    Poster Session 3 • Thursday, 9 September • 9:00-10:30

    Neurophysiology and Neurobiology

    P3.1 Pasqua Abbrescia (Bari)
    Study of AQP4 isoforms localization in the olfactory system and their involvement in the olfactory-mediated behavior

    P3.2 Eleonora Baldini (Verona)
    Target selection, but not distractor suppression, is impaired by single pulse TMS over right Frontal Eye Field

    P3.3 Stefania Bartoletti (Modena)
    Brain repair in temporal lobe epilepsy: an in vivo investigation

    P3.4 Manan Bhatt (Varese)
    Is Betaine a substrate also for GABA transporter 1 (GAT1)?

    P3.5 Daniele Bottai (Milan)
    Movement restraint alters neural stem cells metabolism

    P3.6 Alessio Canovai (Pisa)
    An imbalance in autophagy contributes to retinal damage in the oxygen-induced retinopathy rat model

    P3.7 Francesco Ceccarelli (Rome)
    Stable and dynamic response population coding in prefrontal cortex

    P3.8 Chiara Cerri (Pisa)
    Cognitive and visual function, a simultaneous decline in neuroinflammation

    P3.9 Giulia Curia (Modena)
    Long-term behavioral and histological profile following CA3 ventral lesion

    P3.10 Claudio Del Percio (Rome)
    Sex affects resting state alpha electroencephalographic rhythms in cognitively unimpaired seniors and patients with Alzheimer’s disease and amnesic mild cognitive impairment

    P3.11 Danila Di Domenico (Pavia)
    Combined dopaminergic and gabaergic regulation of prefrontal cortex activity by the cerebellum in anesthetized mice

    P3.12 Marco Emili (Bologna)
    The Ts65Dn mouse model of DS shows dendritic alterations in neocortical pyramidal neurons at early life stages

    P3.13 Mariarita Galbiati (Milan)
    Androgen receptor with an elongated polyglutamine tract dysregulates muscle expression of myo-miRs and of their target genes

    P3.14 Daniele Gallo (Palermo)
    Role of endocannabinoids and TRPV1 channels in the bioelectric activity of hippocampal neurons

    P3.15 Divya Garhwal (Novara)
    Role of the neurovascular unit (NVU) and of the redox state in the amyotrophic lateral sclerosis pathogenesis

    P3.16 Giorgio Grasselli (Genoa)
    Cerebellar climbing fibers can undergo activity-dependent structural plasticity

    P3.17 Marco Greco (Lecce)
    Copper-mediated PLK2 protein modulation in α-synuclein phosphorylation process in Parkinson’s disease

    P3.18 Elena Grossini (Novara)
    Misophonia: analysis of the neuroanatomic patterns at the basis of vegetative and psychiatric symptoms

    P3.19 Maryamsadat Hahemi (Monza)
    CaV3.2 channel as a keystone to clear up differential Bortezomib and Carfilzomib neurotoxicity 

    P3.20 Dominga Lapi (Pisa)
    Imbalance in Angiotensin II/Angiotensin 1-7 system affects pial microcirculation during rat brain hypoperfusion and reperfusion

    P3.21 Roberta Lizio (Rome)
    Age affects resting state alpha electroencephalographic rhythms in cognitively unimpaired seniors and patients with Alzheimer’s disease and amnesic mild cognitive impairment

    P3.22 Nicola Loi (Sassari)
    Motor and perceptual aspects of face emotional expressions in young and aged subjects

    P3.23 Fabrizio Londei (Rome)
    Formation of cell assemblies in the prefrontal cortex of macaque monkeys during a distance and a temporal discrimination task

    P3.24 Algerta Marku (Milan)
    LRRK2 phosphorylation on serine 935 impacts on synaptic vesicle trafficking

    P3.25 Stefano Masoli (Pavia)
    Biophysically realistic computational models of mouse and human Purkinje cells

    Poster Session 4 • Thursday, 9 September • 11:00-12:30

    Neurophysiology and Neurobiology

    P3.26 Francesca Massenzio (Bologna)
    Activation of human microglia clone 3 (HMC3) in response to stress conditions: are long non-coding RNAs involved?

    P3.27 Barbara Monti (Bologna)
    Histone acetylation defects in brain precursor cells: a potential pathogenic mechanism of AGC1 deficiency proliferation/differentiation dysfunction

    P3.28 Alessandra Occhinegro (Bologna)
    The splanchnic anti-inflammatory pathway dampens down the inflammatory response induced by different immune challenges in mice

    P3.29 Alessandra Ottaviani (Pavia)
    High-density multielectrode array recordings reveal computational complexity in cerebellar cortical processing

    P3.30 Emiliana Piscitiello (Bologna)
    Sleep-related effects on the degree of Tau protein phosphorylation following the induction of synthetic torpor in the rat

    P3.31 Bernardo Puccio (Palermo)
    Orally administered indicaxanthin is able to modulate human motor cortical excitability and plasticity

    P3.32 Milena Raffi (Bologna)
    The speed of optic flow stimuli modulates microsaccades’ characteristics

    P3.33 Francesca Raffin (Pavia)
    Effect exerted by the vasoactive intestinal polypeptide on the neurons of the subparaventricular zone

    P3.34 Surabhi Ramawat (Rome)
    Differences in task-difficulty encoding during logical decision-making in prefrontal and premotor cortical activity from non-human primates

    P3.35 Martina Rizza (Pavia)
    Local inhibitory circuits regulate frequency-dependent transmission in the cerebellar molecular layer

    P3.36 Clarissa Rosato (Milan)
    Functional alterations in a Müller cell line: potential implications in diabetic retinopathy

    P3.37 Maria Grazia Rossino (Pisa)
    Antioxidant efficacy of a nature-inspired Nrf2 activator in retinal explants

    P3.38 Miriana Scordino (Palermo)
    New neuroprotective effect of lemon IntegroPectin on neuronal SH-SY5Y cells

    P3.39 Teresa Soda (Pavia)
    Prefrontal cortex hyperexcitability in the IB2 KO mouse model of autism

    P3.40 Teresa Sorbo (Pavia)
    Dendritic processing implements spike-timing dependent plasticity (STDP) in cerebellar Golgi cells

    P3.41 Federica Spitale (Catania)
    Immune cells phenotype modulation in motoneuronal depleted spinal cord targeting sonic hedgehog signaling

    P3.42 Marialuisa Tognolina (Pavia)
    The cerebellar cortex microcircuit functioning investigated by two-photon calcium imaging experiments

    P3.43 Filippo Torrisi (Catania)
    Metabolism and autophagy modulation in heterotopic mouse model of glioblastoma after proton boron capture therapy

    P3.44 Onofrio Valente (Bari)
    Involvement of AQP4ex In edema tumor associated and in blood bran barrier (BBB) damage in human glioblastoma

    P3.45 Nunzio Vicario (Catania)
    Metabolic rebalancing and neuromuscular plasticity in a mouse model of motoneuronal loss

    Physiology of Motor System and Exercise

    P4.1 Alessio Di Clemente (Genoa)
    Biomechanics of the octopus arm muscular hydrostat

    P4.2 Roberto Esposti (Milan)
    Dual-hemisphere tDCS on parietal operculum does not affect the programming of intra-limb anticipatory postural adjustments

    P4.3 Isabel Marc (Rome)
    Failure of the race model accounting for inhibition in a stop signal selective task of upper and lower limb

    P4.4 Gianluca Martinez (Sassari)
    Tongue strength and regular effort saliva swallows measured by piezo-resistive sensors: a test-retest reproducibility study in healthy subjects

    P4.5 Jorge Storniolo (Milan)
    Whole-body cryotherapy rebalances the sympathovagal activity both before and after a maximal exercise

    P4.6 Massimo Teso (Verona)
    An intensity-dependent slow component of HR interferes with accurate exercise implementation in post-menopausal women